Africa is distinguished by a youthful demography, with over 70% of the population under 30 years of age. This synthesis review examines the non-profit sector’s contribution to creating dignified and fulfilling work for African young people. Based on country-level literature reviews from 17 African countries, the report reveals the sector’s key roles in providing employment, skills development, education, entrepreneurship, and policy advocacy. While data gaps hinder precise quantification, the report finds that NPOs and social enterprises offer direct and indirect opportunities for youth employment across key sub-sectors such as education, agriculture, ICT, and health. The report recommends policy advocacy, funding diversification, and strategic partnerships to enhance NPO impact and highlights areas for future empirical research.